Sulla via del Dolore - The path of Pain

• Main Authors: Francesco Amato, Erminia Gilda Morrone
• Format: Article
• Language: English
• Published: Publiediting 2017-01-01
• Series: Pathos
• Subjects: Ion channels; TRPV1; pain; analgesia; neuropathic infiammation
• Online Access: https://www.pathos-journal.com/2016_3_173.html

The studies conducted on the employment of the analgesic drug have considered that drugs that had the ability to decrease the firing of impulses that from the periphery they are propagated to the brain. After the cloning of TRPV1,1,2 occurred in the last ten years of research, the focus has shifted to the Transient Receptor Potential (TRPV1) which sees them involved in many inflammatory and neuropathic processes. For these reasons TRPV1 has become a viable drug target for clinical use in the management of pain. This short review will provide a general picture of the physiological and pathophysiological roles of the TRPV1 channel and of their structural, pharmacological and biophysical properties, as therapeutic agents for the management of chronic and neuropathic pain.