Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes

Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes

Calcium dobesilate (CaD) is used effectively in patients with diabetic microvascular disorder, retinopathy, and nephropathy. Here we sought to determine whether it has an effect on cardiomyocytes calcium mishandling that is characteristic of diabetic cardiomyopathy. Cardiomyocytes were sterile isola...

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Bibliographic Details
Main Authors: Jianxin Deng, Xiangsheng Cai, Mingyu Hao, Xueting Liu, Zelong Chen, Haiyan Li, Junying Liu, Yunxiu Liao, Hao Fu, Huiyan Chen, Gangjian Qin, Dewen Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
calcium dobesilate
cardiomyocytes
calcium sparks
hyperglycemia
laser scanning confocal microscope
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.637021/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.637021/full

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