Clinical and Cytometric Study of Immune Involvement in a Heterogeneous Cohort of Subjects With RASopathies and mTORopathies

Clinical and Cytometric Study of Immune Involvement in a Heterogeneous Cohort of Subjects With RASopathies and mTORopathies

RASopathies and mTORopathies are groups of genetic syndromes associated with increased activation of the RAS-MAPK or the PI3K-AKT-mTOR pathway, resulting in altered cell proliferation during embryonic and postnatal development. The RAS-MAPK and the PI3K-AKT-mTOR pathways are connected to each other...

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Bibliographic Details
Main Authors: Erica Valencic, Prisca Da Lozzo, Gianluca Tornese, Elena Ghirigato, Francesco Facca, Elisa Piscianz, Flavio Faletra, Andrea Taddio, Alberto Tommasini, Andrea Magnolato
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pediatrics
Subjects:
RASopathies
mTORopathies
Ras/MAPK
recent bone marrow emigrants
flow cytometry
immune dysregulation
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.703613/full

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