Reconsidering the Role of Cyclooxygenase Inhibition in the Chemotherapeutic Value of NO-Releasing Aspirins for Lung Cancer

Reconsidering the Role of Cyclooxygenase Inhibition in the Chemotherapeutic Value of NO-Releasing Aspirins for Lung Cancer

Nitric oxide-releasing aspirins (NO-aspirins) are aspirin derivatives that are safer than the parent drug in the gastrointestinal context and have shown superior cytotoxic effects in several cancer models. Despite the rationale for their design, the influence of nitric oxide (NO<b><sup>&...

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Bibliographic Details
Main Authors: Antonia Martin-Martin, Andrés Rivera-Dictter, Matías Muñoz-Uribe, Freddy López-Contreras, Jorge Pérez-Laines, Alfredo Molina-Berríos, Rodrigo López-Muñoz
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
non-small-cell lung cancer
NCX4040
NCX4016
nitric oxide
erlotinib
prostaglandin
cyclooxygenase
Online Access:https://www.mdpi.com/1420-3049/24/10/1924

Internet

https://www.mdpi.com/1420-3049/24/10/1924

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