Visualization of murine intranasal dosing efficiency using luminescent Francisella tularensis: effect of instillation volume and form of anesthesia.

Intranasal instillation is a widely used procedure for pneumonic delivery of drugs, vaccine candidates, or infectious agents into the respiratory tract of research mice. However, there is a paucity of published literature describing the efficiency of this delivery technique. In this report we have u...

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Bibliographic Details
Main Authors: Mark A Miller, Jennifer M Stabenow, Jyothi Parvathareddy, Andrew J Wodowski, Thomas P Fabrizio, Xiaowen R Bina, Lillian Zalduondo, James E Bina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3286442?pdf=render