| Summary: | As a metallic biomaterial, titanium (Ti) exhibits excellent biocompatibility, but its osteoinductivity is limited. Therefore, to improve this property, an electrophoretic deposition (EPD) technique was used to coat the Ti surface with Ti<sub>3</sub>C<sub>2</sub> MXene (Ti<sub>3</sub>C<sub>2</sub>), a new class of two-dimensional nanomaterial. Ti<sub>3</sub>C<sub>2</sub> is known to have good biocompatibility and better osteoinductivity than graphene oxide. The coating layer was characterized by a particulate microstructure and exhibited X-ray diffraction and Raman spectroscopy peaks corresponding to the Ti<sub>3</sub>C<sub>2</sub> phase. In vitro cell tests using human mesenchymal stem cells confirmed that the cell attachment and proliferation on Ti<sub>3</sub>C<sub>2</sub>-coated Ti were similar to that of bare Ti, and that the osteoinductivity was significantly enhanced compared with bare Ti.
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