Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?

Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?

β-lactamases (BLs) represent the most frequent cause of antimicrobial resistance in Gram-negative bacteria. Despite the continuous efforts in the development of BL inhibitors (BLIs), new BLs able to hydrolyze the last developed antibiotics rapidly emerge. Moreover, the insurgence rate of effective m...

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Bibliographic Details
Main Authors: Eleonora Gianquinto, Donatella Tondi, Giulia D'Arrigo, Loretta Lazzarato, Francesca Spyrakis
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antibiotics
Subjects:
antimicrobial resistance
β-lactamases
carbapenemases
protein flexibility
intrinsic dynamics
KPC-2
Online Access:https://www.mdpi.com/2079-6382/9/11/833

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