Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma

Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is highly prevalent in China. Here, the authors carry out multi-region sampling of Chinese ESCC samples, and find recurrent ERBB4 mutations, BRCA1/2 variants, and amplification of CD274; together with high levels of genomic and T-cell receptor heterogeneity.

Bibliographic Details
Main Authors: Ting Yan, Heyang Cui, Yong Zhou, Bin Yang, Pengzhou Kong, Yingchun Zhang, Yiqian Liu, Bin Wang, Yikun Cheng, Jiayi Li, Shixing Guo, Enwei Xu, Huijuan Liu, Caixia Cheng, Ling Zhang, Ling Chen, Xiaofei Zhuang, Yu Qian, Jian Yang, Yanchun Ma, Hongyi Li, Fang Wang, Jing Liu, Xuefeng Liu, Dan Su, Yan Wang, Ruifang Sun, Shiping Guo, Yaoping Li, Xiaolong Cheng, Zhihua Liu, Qimin Zhan, Yongping Cui
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09255-1

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