Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is highly prevalent in China. Here, the authors carry out multi-region sampling of Chinese ESCC samples, and find recurrent ERBB4 mutations, BRCA1/2 variants, and amplification of CD274; together with high levels of genomic and T-cell receptor heterogeneity.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09255-1 |
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doaj-6af70de020a14ed99c2762313c23bbe1 |
|---|---|
| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ting Yan Heyang Cui Yong Zhou Bin Yang Pengzhou Kong Yingchun Zhang Yiqian Liu Bin Wang Yikun Cheng Jiayi Li Shixing Guo Enwei Xu Huijuan Liu Caixia Cheng Ling Zhang Ling Chen Xiaofei Zhuang Yu Qian Jian Yang Yanchun Ma Hongyi Li Fang Wang Jing Liu Xuefeng Liu Dan Su Yan Wang Ruifang Sun Shiping Guo Yaoping Li Xiaolong Cheng Zhihua Liu Qimin Zhan Yongping Cui |
| spellingShingle |
Ting Yan Heyang Cui Yong Zhou Bin Yang Pengzhou Kong Yingchun Zhang Yiqian Liu Bin Wang Yikun Cheng Jiayi Li Shixing Guo Enwei Xu Huijuan Liu Caixia Cheng Ling Zhang Ling Chen Xiaofei Zhuang Yu Qian Jian Yang Yanchun Ma Hongyi Li Fang Wang Jing Liu Xuefeng Liu Dan Su Yan Wang Ruifang Sun Shiping Guo Yaoping Li Xiaolong Cheng Zhihua Liu Qimin Zhan Yongping Cui Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma Nature Communications |
| author_facet |
Ting Yan Heyang Cui Yong Zhou Bin Yang Pengzhou Kong Yingchun Zhang Yiqian Liu Bin Wang Yikun Cheng Jiayi Li Shixing Guo Enwei Xu Huijuan Liu Caixia Cheng Ling Zhang Ling Chen Xiaofei Zhuang Yu Qian Jian Yang Yanchun Ma Hongyi Li Fang Wang Jing Liu Xuefeng Liu Dan Su Yan Wang Ruifang Sun Shiping Guo Yaoping Li Xiaolong Cheng Zhihua Liu Qimin Zhan Yongping Cui |
| author_sort |
Ting Yan |
| title |
Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma |
| title_short |
Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma |
| title_full |
Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma |
| title_fullStr |
Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma |
| title_full_unstemmed |
Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma |
| title_sort |
multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-04-01 |
| description |
Esophageal squamous cell carcinoma (ESCC) is highly prevalent in China. Here, the authors carry out multi-region sampling of Chinese ESCC samples, and find recurrent ERBB4 mutations, BRCA1/2 variants, and amplification of CD274; together with high levels of genomic and T-cell receptor heterogeneity. |
| url |
https://doi.org/10.1038/s41467-019-09255-1 |
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doaj-6af70de020a14ed99c2762313c23bbe12021-05-11T12:28:23ZengNature Publishing GroupNature Communications2041-17232019-04-0110111510.1038/s41467-019-09255-1Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinomaTing Yan0Heyang Cui1Yong Zhou2Bin Yang3Pengzhou Kong4Yingchun Zhang5Yiqian Liu6Bin Wang7Yikun Cheng8Jiayi Li9Shixing Guo10Enwei Xu11Huijuan Liu12Caixia Cheng13Ling Zhang14Ling Chen15Xiaofei Zhuang16Yu Qian17Jian Yang18Yanchun Ma19Hongyi Li20Fang Wang21Jing Liu22Xuefeng Liu23Dan Su24Yan Wang25Ruifang Sun26Shiping Guo27Yaoping Li28Xiaolong Cheng29Zhihua Liu30Qimin Zhan31Yongping Cui32Shenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen HospitalDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityShenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen HospitalCollege of Letter & Science, University of California BerkeleyAnglo-Chinese School (Independent)Department of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology, Tianjin Central Hospital of Gynecology Obstetrics, Nankai University Gynecology Obstetrics HospitalDepartment of Tumor Surgery, Shanxi Cancer HospitalDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityShenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen HospitalDepartment of Pathology, Zhejiang Cancer HospitalShenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen HospitalTumor Biobank, Shanxi Cancer HospitalDepartment of Tumor Surgery, Shanxi Cancer HospitalDepartment of Colorectal & Anal Surgery, Affiliated Provincial Hospital of Shanxi Medical UniversityDepartment of Pathology & Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal Cancer, Shanxi Medical UniversityState Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen HospitalEsophageal squamous cell carcinoma (ESCC) is highly prevalent in China. Here, the authors carry out multi-region sampling of Chinese ESCC samples, and find recurrent ERBB4 mutations, BRCA1/2 variants, and amplification of CD274; together with high levels of genomic and T-cell receptor heterogeneity.https://doi.org/10.1038/s41467-019-09255-1 |