Effects of intensive hemoperfusion on the toxin clearance, target organ function and oxidative stress in patient with paraquat poisoning

• Main Authors: Li-Jun Zou, Shu-Hua Li
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-11-01
• Series: Journal of Hainan Medical University
• Subjects: Paraquat poisoning; Intensive hemoperfusion; Toxin clearance; Pulmonary fibrosis; Oxidative stress
• Online Access: http://www.hnykdxxb.com/PDF/201722/18.pdf

Objective: To study the effects of intensive hemoperfusion on the toxin clearance, target organ function and oxidative stress in patient with paraquat poisoning. Methods: A total of 56 patients with paraquat poisoning who were treated in the People’s Hospital of Hanchuan between November 2013 and January 2017 were reviewed and divided into the control group (n=30) and the intensive hemoperfusion group (n=26). Control group received conventional therapy, and intensive hemoperfusion group received conventional therapy combined with intensive hemoperfusion. The differences in paraquat clearance effect, target organ function and oxidative stress response were compared between the two groups. Results: Serum paraquat level in intensive hemoperfusion group was lower than that in control group, and the paraquat clearance rate was higher than that of control group. Serum pulmonary fibrosis indexes PⅠCP, CⅣ and HA levels in intensive hemoperfusion group were lower than those in control group; serum liver function indexes ALP, STB and ALT levels were lower than those in control group; serum oxidative stress index GSH-Px level was higher than that in control group whereas MDA level was lower than that in control group. Conclusion: Intensive hemoperfusion can significantly improve the paraquat clearance rate, protect the important organ function and suppress the systemic oxidative stress response in patient with paraquat poisoning.