PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
PSPC1 has a critical role in promoting EMT and metastasis. Here, the authors demonstrate that PSPC1 is the contextual determinant of the oncogenic switch of PTK6/β-catenin subcellular localizations to drive metastasis of hepatocellular carcinoma cells via a PSPC1/PTK6/β-catenin signaling.
Bibliographic Details
| Main Authors: |
Yaw-Dong Lang,
Hsin-Yi Chen,
Chun-Ming Ho,
Jou-Ho Shih,
En-Chi Hsu,
Roger Shen,
Yu-Ching Lee,
Jyun-Wei Chen,
Cheng-Yen Wu,
Hsi-Wen Yeh,
Ruey-Hwa Chen,
Yuh-Shan Jou |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-13665-6
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