Influence of ginkgo leaf tablets combined with nifedipine tablets treatment on relevant indexes of prethrombotic state in hypertension patients

• Main Authors: Ping Zhou, Xiu-Hong Liu, Ya-Ping Du, Xiao-Xia Han, Guo-Mei Dan
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-03-01
• Series: Journal of Hainan Medical University
• Subjects: Ginkgo leaf tablets; Nifedipine; Hypertension; Blood pressure; Hemorheology; Prethrombotic state
• Online Access: http://www.jhmuweb.net/PDF/201605/6.pdf

Objective: To explore the influence of ginkgo leaf tablets combined with nifedipine tablets treatment on the relevant indexes of prethrombotic state in hypertension patients. Methods: A total of 80 cases with hypertension were selected, who were admitted in our hospital from May 2014 to June 2015, and all of whom was randomly divided into study group and control group (n=40). Patients in study group were given ginkgo leaf tablets combined with nifedipine tablets treatment, while patients in control group were given nifedipine tablets treatment only. The changes of blood pressure indexes between groups before and after treatment were compared. the changes of hemodynamic indexes between groups before and after treatment were analyzed. And the changes of molecular markers of prethrombotic state between groups before and after treatment were observed. Results: Before treatment, comparative difference of systolic pressure, diastolic pressure levels, hemodynamic indexes(MH, ML, MP, HCT, ESR, AI), VWF, GMP, D-dimer and PAI-1 levels between groups had no statistical significance (P>0.05); while after treatment, systolic pressure, diastolic pressure levels, hemodynamic indexes(MH, ML, MP, HCT, ESR, AI), VWF, GMP, D-dimer and PAI-1 levels in both groups were obviously lower than before treatment (P<0.05), but systolic pressure, diastolic pressure levels, MH, ML, MP, ESR, VWF, GMP, D-dimer and PAI-1 levels in study group were lower than that in control group, and the difference had statistical significance (P<0.05), after treatment, the four index levels in both groups were significantly lower than before treatment (P<0.05). Conclusions: Ginkgo leaf tablets combined with nifedipine tablets in the treatment of hypertension patients could significantly reduce the systolic pressure, diastolic pressure levels, reduce the levels of hemodynamic indexes (MH, ML, MP, HCT, ESR, AI) and reduce the levels of molecular markers (VWF, GMP, D-dimer , PAI-1) of prethrombotic state, which was an effective therapeutic method.