Fibrotic microtissue array to predict anti-fibrosis drug efficacy

A bottleneck in developing new anti-fibrosis therapies is the absence of suitable in vitro models that recapitulate key features of fibrogenesis. Here the authors develop a tissue-on-a-chip model of lung fibrosis and test the therapeutic efficacy of two recent FDA-approved drugs.

Bibliographic Details
Main Authors:	Mohammadnabi Asmani, Sanjana Velumani, Yan Li, Nicole Wawrzyniak, Isaac Hsia, Zhaowei Chen, Boris Hinz, Ruogang Zhao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04336-z

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spelling	doaj-6ac76a78833f45c899ebfb821c22460e2021-05-11T10:32:59ZengNature Publishing GroupNature Communications2041-17232018-05-019111210.1038/s41467-018-04336-zFibrotic microtissue array to predict anti-fibrosis drug efficacyMohammadnabi Asmani0Sanjana Velumani1Yan Li2Nicole Wawrzyniak3Isaac Hsia4Zhaowei Chen5Boris Hinz6Ruogang Zhao7Department of Biomedical Engineering, University at Buffalo, The State University of New YorkDepartment of Biomedical Engineering, University at Buffalo, The State University of New YorkDepartment of Biomedical Engineering, University at Buffalo, The State University of New YorkDepartment of Biomedical Engineering, University at Buffalo, The State University of New YorkDepartment of Biomedical Engineering, University at Buffalo, The State University of New YorkDepartment of Biomedical Engineering, University at Buffalo, The State University of New YorkLaboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of TorontoDepartment of Biomedical Engineering, University at Buffalo, The State University of New YorkA bottleneck in developing new anti-fibrosis therapies is the absence of suitable in vitro models that recapitulate key features of fibrogenesis. Here the authors develop a tissue-on-a-chip model of lung fibrosis and test the therapeutic efficacy of two recent FDA-approved drugs.https://doi.org/10.1038/s41467-018-04336-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mohammadnabi Asmani Sanjana Velumani Yan Li Nicole Wawrzyniak Isaac Hsia Zhaowei Chen Boris Hinz Ruogang Zhao
spellingShingle	Mohammadnabi Asmani Sanjana Velumani Yan Li Nicole Wawrzyniak Isaac Hsia Zhaowei Chen Boris Hinz Ruogang Zhao Fibrotic microtissue array to predict anti-fibrosis drug efficacy Nature Communications
author_facet	Mohammadnabi Asmani Sanjana Velumani Yan Li Nicole Wawrzyniak Isaac Hsia Zhaowei Chen Boris Hinz Ruogang Zhao
author_sort	Mohammadnabi Asmani
title	Fibrotic microtissue array to predict anti-fibrosis drug efficacy
title_short	Fibrotic microtissue array to predict anti-fibrosis drug efficacy
title_full	Fibrotic microtissue array to predict anti-fibrosis drug efficacy
title_fullStr	Fibrotic microtissue array to predict anti-fibrosis drug efficacy
title_full_unstemmed	Fibrotic microtissue array to predict anti-fibrosis drug efficacy
title_sort	fibrotic microtissue array to predict anti-fibrosis drug efficacy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-05-01
description	A bottleneck in developing new anti-fibrosis therapies is the absence of suitable in vitro models that recapitulate key features of fibrogenesis. Here the authors develop a tissue-on-a-chip model of lung fibrosis and test the therapeutic efficacy of two recent FDA-approved drugs.
url	https://doi.org/10.1038/s41467-018-04336-z
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Fibrotic microtissue array to predict anti-fibrosis drug efficacy

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