Fibrotic microtissue array to predict anti-fibrosis drug efficacy

A bottleneck in developing new anti-fibrosis therapies is the absence of suitable in vitro models that recapitulate key features of fibrogenesis. Here the authors develop a tissue-on-a-chip model of lung fibrosis and test the therapeutic efficacy of two recent FDA-approved drugs.

Bibliographic Details
Main Authors: Mohammadnabi Asmani, Sanjana Velumani, Yan Li, Nicole Wawrzyniak, Isaac Hsia, Zhaowei Chen, Boris Hinz, Ruogang Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04336-z