Massively parallel interrogation of aptamer sequence, structure and function.

Massively parallel interrogation of aptamer sequence, structure and function.

BACKGROUND: Optimization of high affinity reagents is a significant bottleneck in medicine and the life sciences. The ability to synthetically create thousands of permutations of a lead high-affinity reagent and survey the properties of individual permutations in parallel could potentially relieve t...

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Bibliographic Details
Main Authors: Nicholas O Fischer, Jeffrey B-H Tok, Theodore M Tarasow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2444025?pdf=render

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