Prediction of Prostatic Involvement by Transitional Cell Carcinoma of the Bladder Using Pathologic Characteristics of the Bladder Tumor

• Main Authors: Sorayya Khafri, Hamidreza Abdi, Behrang Abadpour, Mahmoud Parvin, Nasser Simforoosh, Ali Tabibi
• Format: Article
• Language: English
• Published: Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences 2006-02-01
• Series: Urology Journal
• Online Access: http://www.urologyjournal.org/index.php/uj/article/view/186
• ISSN: 1735-1308; 1735-546X

<p class="MsoNormal" style="margin: 0cm -4.1pt 0pt 0cm;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong style="mso-bidi-font-weight: normal;"><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Lotus';">Introduction:</span></strong><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Lotus'; mso-bidi-font-weight: bold;"> The</span><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Lotus';"> aim of this prospective study is to determine the relationship between the pathologic characteristics of the transitional cell carcinoma (TCC) of the bladder and prostatic involvement.<strong style="mso-bidi-font-weight: normal;"></strong></span></span></span></p><p class="MsoNormal" style="margin: 0cm -4.1pt 0pt 0cm;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong style="mso-bidi-font-weight: normal;"><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Lotus';">Materials and Methods:</span></strong><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Lotus'; mso-bidi-font-weight: bold;"> Sixty</span><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Lotus';"> men with bladder TCC underwent standard radical cystoprostatectomy and were enrolled in this study. Vascular and perineural invasion, maximum diameter of the tumor, presence of carcinoma in situ, distance between the tumor and the bladder neck, and grade and local stage of the tumor were recorded and their relation with prostatic involvement was studied. In addition, hydronephrosis and age of the patients were included in the analysis.</span></span></span></p><p class="MsoNormal" style="margin: 0cm -4.1pt 0pt 0cm;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong style="mso-bidi-font-weight: normal;"><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Lotus';">Results: </span></strong><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Lotus';">The mean age of the patients was 63.9</span><span style="mso-bidi-language: FA;"> ± 11.1 years. </span><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Lotus';">Of 60 men included in this study, </span><span style="mso-bidi-language: FA;">15 patients were found to have prostatic involvement with TCC (25%). </span><span style="color: #000000;">Univariate statistical analyses </span><span style="mso-bidi-language: FA;">showed that vascular invasion and the distance between the tumor and the bladder neck were significantly related to the prostatic involvement (<em>P</em> = .007; <em>P</em> < .001). But, in the </span><span style="color: #000000;">logistic regression, </span><span style="mso-bidi-language: FA;">only the distance between the tumor and the bladder neck was significantly related to the prostatic involvement (<em>P</em> = .001).</span><strong style="mso-bidi-font-weight: normal;"></strong></span></span></p><p class="MsoNormal" style="margin: 0cm 0cm 0pt;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong style="mso-bidi-font-weight: normal;"><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Lotus';">Conclusion:</span></strong><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Lotus';"> This study suggests that the probability of prostatic involvement in patients with bladder TCC tumors near the bladder neck is high. Prostate-sparing or capsule-sparing cystectomy should be avoided in such patients.</span></span></span></p>