Development and Application of a Water Temperature Related Physiologically Based Pharmacokinetic Model for Enrofloxacin and Its Metabolite Ciprofloxacin in Rainbow Trout

Development and Application of a Water Temperature Related Physiologically Based Pharmacokinetic Model for Enrofloxacin and Its Metabolite Ciprofloxacin in Rainbow Trout

Enrofloxacin (ENR) has been approved for the treatment of infections in aquaculture, but it may cause tissue residue. This research aimed to develop and validate a water temperature related PBPK model, including both ENR and ciprofloxacin (CIP), in rainbow trout, and to predict further their residue...

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Bibliographic Details
Main Authors: Fan Yang, Fang Yang, Dan Wang, Chao-Shuo Zhang, Han Wang, Zhe-Wen Song, Hao-Tian Shao, Mei Zhang, Meng-Li Yu, Yang Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Veterinary Science
Subjects:
enrofloxacin
ciprofloxacin
rainbow trout
physiologically based pharmacokinetic model
water temperature
residue
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2020.608348/full

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