Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.

Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.

The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-α (HIF1α) through inhibition of prolyl hydrolase 2 (PHD2) and activati...

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Main Authors: Yu-Yo Sun, Shang-Hsuan Lin, Hung-Cheng Lin, Chia-Chi Hung, Chen-Yu Wang, Yen-Chu Lin, Kuo-Sheng Hung, Cheng-Chang Lien, Chia-Yi Kuan, Yi-Hsuan Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3719842?pdf=render

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