Second-Generation Histamine H1 Receptor Antagonists Suppress Delayed Rectifier K+-Channel Currents in Murine Thymocytes

Second-Generation Histamine H1 Receptor Antagonists Suppress Delayed Rectifier K+-Channel Currents in Murine Thymocytes

Background/Aims. Voltage-dependent potassium channels (Kv1.3) are predominantly expressed in lymphocyte plasma membranes. These channels are critical for the activation and proliferation of lymphocytes. Since second-generation antihistamines are lipophilic and exert immunomodulatory effects, they ar...

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Bibliographic Details
Main Authors:	Kazutomo Saito, Nozomu Abe, Hiroaki Toyama, Yutaka Ejima, Masanori Yamauchi, Hajime Mushiake, Itsuro Kazama
Format:	Article
Language:	English
Published:	Hindawi Limited 2019-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2019/6261951

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