Suppression of Connexin 43 Leads to Strial Vascular Hyper-Permeability, Decrease in Endocochlear Potential, and Mild Hearing Loss

Suppression of Connexin 43 Leads to Strial Vascular Hyper-Permeability, Decrease in Endocochlear Potential, and Mild Hearing Loss

Objective: Connexin 43 (Cx43) is a protein constituent of gap junctions (GJs) in various barrier cells, especially astrocytes and microglia of the blood-brain-barrier (BBB), where it plays an important role in intercellular communication and regulation of the barrier. Despite the importance of Cx43...

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Bibliographic Details
Main Authors: Jinhui Zhang, Xiaohan Wang, Zhiqiang Hou, Lingling Neng, Jing Cai, Yunpei Zhang, Xiaorui Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Physiology
Subjects:
mouse
connexin 43
blood-labyrinth-barrier
perivascular macrophage
endocochlear potential
hearing loss
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00974/full

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