PARP inhibitors – theoretical basis and clinical application

PARP inhibitors – theoretical basis and clinical application

 Poly-ADP-ribose polymerases (PARP) are involved in a number of processes that are vital for every living cell. Once activated by the presence of DNA damage they trigger poly-ADP-ribosylation of various proteins which are crucial for DNA repair, preserving of genom integrity, regulation of transcrip...

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Bibliographic Details
Main Authors: Sylwia Dębska, Joanna Kubicka, Rafał Czyżykowski, Maja Habib, Piotr Potemski
Format: Article
Language:English
Published: Index Copernicus International S.A. 2012-05-01
Series:Postępy Higieny i Medycyny Doświadczalnej
Subjects:
synthetic lethality
poly-ADP-ribose polymerase
Base excision repair
homologous recombination repair
Nonhomologous end joining
BRCA1/2 genes
ovarian cancer
Triple negative breast cancer
Online Access:http://journals.indexcopernicus.com/fulltxt.php?ICID=999033

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