Development of a Novel Antimicrobial Screening System Targeting the Pyoverdine-Mediated Iron Acquisition System and Xenobiotic Efflux Pumps

Development of a Novel Antimicrobial Screening System Targeting the Pyoverdine-Mediated Iron Acquisition System and Xenobiotic Efflux Pumps

The iron acquisition systems in Pseudomonas aeruginosa are inducible in response to low-iron conditions and important for growth of this organism under iron limitation. OprM is the essential outer membrane subunit of the MexAB-OprM xenobiotic efflux pump. We designed and constructed a new model anti...

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Bibliographic Details
Main Authors: Kazuki Sato, Kenichi Ushioda, Keiji Akiba, Yoshimi Matsumoto, Hideaki Maseda, Tasuke Ando, Emiko Isogai, Taiji Nakae, Hiroshi Yoneyama
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Molecules
Subjects:
antimicrobials
iron acquisition systems
efflux pumps
Pseudomonas aeruginosa
Online Access:http://www.mdpi.com/1420-3049/20/5/7790

Internet

http://www.mdpi.com/1420-3049/20/5/7790

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