Nephrotic syndrome after treatment of Crohn′s disease with mesalamine: Case report and literature review

• Main Authors: Belal M Firwana, Rim Hasan, Walid Chalhoub, Mazen Ferwana, Jin-Yong Kang, Joshua Aron, Joseph Lieber
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2012-01-01
• Series: Avicenna Journal of Medicine
• Subjects: aminosalicylic acid; crohn′s disease; inflammatory bowel disease; mesalamine; minimal change disease; nephrotic syndrome
• Online Access: http://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.94804
• ISSN: 2231-0770; 2249-4464

Inflammatory bowel disease and its various treatments may affect the kidney in several ways. Recently, case reports have been published documenting the development of nephrotic syndrome after the treatment for inflammatory bowel disease with 5-aminosalicylic acid derivatives. We report a 50-year-old patient who was diagnosed with Crohn′s disease and was treated with mesalamine. The patient subsequently developed nephrotic syndrome and a renal biopsy showed minimal change disease. He was treated with losartan and rosuvastatin and showed improvement in his renal function and serum cholesterol level. This is the first reported case in Crohn′s disease although there have been six previous case reports of nephrotic syndrome following salicylic acid derivatives for ulcerative colitis.