USP18 is a significant driver of memory CD4 T-cell reduced viability caused by type I IFN signaling during primary HIV-1 infection.

USP18 is a significant driver of memory CD4 T-cell reduced viability caused by type I IFN signaling during primary HIV-1 infection.

The loss of Memory CD4 T-cells (Mem) is a major hallmark of HIV-1 immuno-pathogenesis and occurs early during the first months of primary infection. A lot of effort has been put into understanding the molecular mechanisms behind this loss, yet they still have not been fully identified. In this study...

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Bibliographic Details
Main Authors: Xavier Dagenais-Lussier, Hamza Loucif, Hugo Cadorel, Juliette Blumberger, Stéphane Isnard, Mariana Gé Bego, Éric A Cohen, Jean-Pierre Routy, Julien van Grevenynghe, Montreal Primary Infection Study Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008060

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