CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis

CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis

Blastomyces dermatitidis is a human fungal pathogen of the lung that can lead to disseminated disease in healthy and immunocompromised individuals. Genetic analysis of this fungus is hampered by the relative inefficiency of traditional recombination-based gene-targeting approaches. Here, we demonstr...

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Bibliographic Details
Main Authors: Gregory C. Kujoth, Thomas D. Sullivan, Richard Merkhofer, Taek-Jin Lee, Huafeng Wang, Tristan Brandhorst, Marcel Wuthrich, Bruce S. Klein, Joseph Heitman
Format: Article
Language:English
Published: American Society for Microbiology 2018-04-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/9/2/e00412-18

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http://mbio.asm.org/cgi/content/full/9/2/e00412-18

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