| Summary: | Image reconstruction in optoacoustic imaging is often based on a delay-and-sum (DAS) or a frequency domain (FD) algorithm. In this study, we performed a comprehensive comparison of these two algorithms together with coherence factor (CF) weighting using phantom and in-vivo mouse data obtained with optoacoustic microscopy. For this purpose we developed an FD based definition of the CF. Our results reveal the equivalence of DAS and FD, with and without CF weighting, in terms of spatial resolution and contrast-to-noise ratio (CNR) but highlight the clear advantage of FD in terms of computational cost, making it preferable for 3D reconstruction or real-time applications. An important additional result of this research is that, contradictory to previous studies, CF weighting does not lead to any improvement in lateral resolution. Keywords: Photoacoustic, Synthetic aperture focusing technique, Lateral resolution, In-vivo, Optoacoustic microscopy
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