New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation

The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease. Being able to target and eliminate cccDNA is the...

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Bibliographic Details
Main Authors: Alexander L. Marchetti, Haitao Guo
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/9/11/2430