Crk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer

Crk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer

The tumor infiltration of immune cells in solid cancers can profoundly influence host antitumor responses. In recent years, immunotherapeutic regimens, that target immune checkpoints, demonstrated significant antitumor response by increasing intra-tumoral immune cell populations, including CD8+ effe...

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Bibliographic Details
Main Authors: Sushil Kumar, Viralkumar Davra, Alison E. Obr, Ke Geng, Teresa L. Wood, Mariana S. De Lorenzo, Raymond B. Birge
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:OncoImmunology
Subjects:
breast cancer
crk
metastasis
pd-l1
tumor immunity
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1376155

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