Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes

Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes

Abstract Background Histones undergo extensive post-translational modifications and this epigenetic regulation plays an important role in modulating transcriptional programs capable of driving cancer progression. Acetylation of histone H3K18, associated with gene activation, is enhanced by P300 and...

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Bibliographic Details
Main Authors: Shivashankar Damodaran, Nathan Damaschke, Joseph Gawdzik, Bing Yang, Cedric Shi, Glenn O. Allen, Wei Huang, John Denu, David Jarrard
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Cancer
Subjects:
Epigenetic modifications in PCa
Histone H3 acetylation
Cancer progression
SIRT2 loss
Online Access:http://link.springer.com/article/10.1186/s12885-017-3853-9

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