Hydroxycobalamin catalyzes the oxidation of diethyldithiocarbamate and increases its cytotoxicity independently of copper ions

Hydroxycobalamin catalyzes the oxidation of diethyldithiocarbamate and increases its cytotoxicity independently of copper ions

It is known that some metals (Cu, Zn, Cd, Au) markedly increase the toxic effect of thiocarbamates. It was shown in the present study that hydroxycobalamin (a form of vitamin B12, HOCbl), which incorporates cobalt, significantly enhances the cytotoxicity of diethyldithiocarbamate (DDC), decreasing i...

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Bibliographic Details
Main Authors:	M.E. Solovieva, Yu.V. Shatalin, V.V. Solovyev, A.V. Sazonov, V.P. Kutyshenko, V.S. Akatov
Format:	Article
Language:	English
Published:	Elsevier 2019-01-01
Series:	Redox Biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S221323171830586X

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