Generation of induced pluripotent stem cell line (ZZUi004-A) from urine sample of a patient with spinocerebellar ataxia type 3

Generation of induced pluripotent stem cell line (ZZUi004-A) from urine sample of a patient with spinocerebellar ataxia type 3

Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disease caused by a CAG repeat expansion in the region of the ATXN3 gene. The main feature of SCA3 is progressive ataxia, which affects balance, gait, and speech. Urine cells (UCs) of a SCA3 patient were successfully tr...

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Main Authors: Yanlin Wang, Changhe Shi, Zhilei Wang, Huifang Sun, Zhihua Yang, Fan Zhang, Yutao Liu, Han Liu, Chenyang Jiang, Shoutao Zhang, Yuming Xu, Xuejun Wen
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506118300308
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spelling doaj-6a574f1334d548e685022ebe82c6293c2020-11-24T22:28:19ZengElsevierStem Cell Research1873-50612018-04-01287174Generation of induced pluripotent stem cell line (ZZUi004-A) from urine sample of a patient with spinocerebellar ataxia type 3Yanlin Wang0Changhe Shi1Zhilei Wang2Huifang Sun3Zhihua Yang4Fan Zhang5Yutao Liu6Han Liu7Chenyang Jiang8Shoutao Zhang9Yuming Xu10Xuejun Wen11Department of Neurology, The First affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, ChinaDepartment of Neurology, The First affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, ChinaDepartment of Neurology, The First affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, ChinaDepartment of Neurology, The First affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, ChinaDepartment of Neurology, The First affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, ChinaDepartment of Geriatrics, The Second affiliated Hospital of Zhengzhou University, Zhengzhou 450014, Henan, ChinaDepartment of Neurology, The First affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, ChinaDepartment of Neurology, The First affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, ChinaDepartment of Neurology, The First affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, ChinaSchool of life sciences, Zhengzhou University, Zhengzhou, Henan 450001, ChinaDepartment of Neurology, The First affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China; Corresponding author.Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, USA; Shanghai East Hospital, The Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine, Shanghai 200120, China; Correspondence to: Xuejun Wen, Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, USA.Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disease caused by a CAG repeat expansion in the region of the ATXN3 gene. The main feature of SCA3 is progressive ataxia, which affects balance, gait, and speech. Urine cells (UCs) of a SCA3 patient were successfully translated to induced pluripotent stem cells (iPSCs) by using the Sendai virus delivery system. ZZUi004-A cell line may provide a robust platform for further study of SCA3 pathogenesis as well as drug testing and gene therapy research.http://www.sciencedirect.com/science/article/pii/S1873506118300308
collection DOAJ
language English
format Article
sources DOAJ
author Yanlin Wang
Changhe Shi
Zhilei Wang
Huifang Sun
Zhihua Yang
Fan Zhang
Yutao Liu
Han Liu
Chenyang Jiang
Shoutao Zhang
Yuming Xu
Xuejun Wen
spellingShingle Yanlin Wang
Changhe Shi
Zhilei Wang
Huifang Sun
Zhihua Yang
Fan Zhang
Yutao Liu
Han Liu
Chenyang Jiang
Shoutao Zhang
Yuming Xu
Xuejun Wen
Generation of induced pluripotent stem cell line (ZZUi004-A) from urine sample of a patient with spinocerebellar ataxia type 3
Stem Cell Research
author_facet Yanlin Wang
Changhe Shi
Zhilei Wang
Huifang Sun
Zhihua Yang
Fan Zhang
Yutao Liu
Han Liu
Chenyang Jiang
Shoutao Zhang
Yuming Xu
Xuejun Wen
author_sort Yanlin Wang
title Generation of induced pluripotent stem cell line (ZZUi004-A) from urine sample of a patient with spinocerebellar ataxia type 3
title_short Generation of induced pluripotent stem cell line (ZZUi004-A) from urine sample of a patient with spinocerebellar ataxia type 3
title_full Generation of induced pluripotent stem cell line (ZZUi004-A) from urine sample of a patient with spinocerebellar ataxia type 3
title_fullStr Generation of induced pluripotent stem cell line (ZZUi004-A) from urine sample of a patient with spinocerebellar ataxia type 3
title_full_unstemmed Generation of induced pluripotent stem cell line (ZZUi004-A) from urine sample of a patient with spinocerebellar ataxia type 3
title_sort generation of induced pluripotent stem cell line (zzui004-a) from urine sample of a patient with spinocerebellar ataxia type 3
publisher Elsevier
series Stem Cell Research
issn 1873-5061
publishDate 2018-04-01
description Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disease caused by a CAG repeat expansion in the region of the ATXN3 gene. The main feature of SCA3 is progressive ataxia, which affects balance, gait, and speech. Urine cells (UCs) of a SCA3 patient were successfully translated to induced pluripotent stem cells (iPSCs) by using the Sendai virus delivery system. ZZUi004-A cell line may provide a robust platform for further study of SCA3 pathogenesis as well as drug testing and gene therapy research.
url http://www.sciencedirect.com/science/article/pii/S1873506118300308
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