<i>Staphylococcus aureus</i> Decreases SUMOylation Host Response to Promote Intramacrophage Survival

<i>Staphylococcus aureus</i> Decreases SUMOylation Host Response to Promote Intramacrophage Survival

<i>Staphylococcus aureus</i> is a commensal bacterium that causes severe infections in soft tissue and the bloodstream. During infection, <i>S. aureus</i> manipulates host cell response to facilitate its own replication and dissemination. Here, we show that <i>S. aureus...

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Bibliographic Details
Main Authors: Nadhuma Youssouf, Clara Recasens-Zorzo, Virginie Molle, Guillaume Bossis, Philippe Soubeyran, Laila Gannoun-Zaki
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Staphylococcus aureus</i>
SUMOylation
infection
Ubc9
intracellular survival
macrophage
Online Access:https://www.mdpi.com/1422-0067/22/15/8108
Description
Summary:<i>Staphylococcus aureus</i> is a commensal bacterium that causes severe infections in soft tissue and the bloodstream. During infection, <i>S. aureus</i> manipulates host cell response to facilitate its own replication and dissemination. Here, we show that <i>S. aureus</i> significantly decreases the level of SUMOylation, an essential post-translational modification, in infected macrophages 24 h post-phagocytosis. The reduced level of SUMOylation correlates with a decrease in the SUMO-conjugating enzyme Ubc9. The over-expression of SUMO proteins in macrophages impaired bacterial intracellular proliferation and the inhibition of SUMOylation with ML-792 increased it. Together, these findings demonstrated for the first time the role of host SUMOylation response toward <i>S. aureus</i> infection.
ISSN:1661-6596
1422-0067

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