Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice

Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice

Background and Aim: To investigate whether double-knockdown of PHD1 and Keap1 in mice could enhance the resolution of carbon tetrachloride (CCl4)-induced liver fibrosis.Methods: The liver fibrosis model of mice was established by intraperitoneal injection of 25% CCl4 in olive oil (4 ul/g) twice a we...

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Bibliographic Details
Main Authors: Jing Liu, Wencai Li, Manoj H. Limbu, Yiping Li, Zhi Wang, Zhengyuan Cheng, Xiaoyi Zhang, Pingsheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
liver fibrosis
hepatocytes
PHD1
Keap1
hypoxia
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00555/full

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