Treg and Oligoclonal Expansion of Terminal Effector CD8+ T Cell as Key Players in Multiple Myeloma

Treg and Oligoclonal Expansion of Terminal Effector CD8+ T Cell as Key Players in Multiple Myeloma

The classical paradigm of host-tumor interaction, i.e. elimination, equilibrium, and escape (EEE), is reflected in the clinical behavior of myeloma which progresses from the premalignant condition, Monoclonal Gammopathy of Unknown Significance (MGUS). Despite the role of other immune cells, CD4+ reg...

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Bibliographic Details
Main Authors: Douglas E. Joshua, Slavica Vuckovic, James Favaloro, Ka Hei Aleks Lau, Shihong Yang, Christian E. Bryant, John Gibson, Phoebe Joy Ho
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
T cells
myeloma
oligoclonal expansions
CD69+TTE
CD39-Treg
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.620596/full

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