Contributory role of five common polymorphisms of RAGE and APE1 genes in lung cancer among Han Chinese.

Lung cancer is the leading cause of cancer mortality in China. Given the ubiquitous nature of gene-to-gene interaction in lung carcinogenesis, we sought to evaluate five common polymorphisms from advanced glycosylation end product-specific receptor (RAGE) and apurinic/apyrimidinic endonuclease 1 (AP...

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Main Authors: Hongming Pan, Wenquan Niu, Lan He, Bin Wang, Jun Cao, Feng Zhao, Ying Liu, Shen Li, Huijian Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3708913?pdf=render
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spelling doaj-6a284320cfe84d03b4dcf962839fe4732020-11-25T02:33:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e6901810.1371/journal.pone.0069018Contributory role of five common polymorphisms of RAGE and APE1 genes in lung cancer among Han Chinese.Hongming PanWenquan NiuLan HeBin WangJun CaoFeng ZhaoYing LiuShen LiHuijian WuLung cancer is the leading cause of cancer mortality in China. Given the ubiquitous nature of gene-to-gene interaction in lung carcinogenesis, we sought to evaluate five common polymorphisms from advanced glycosylation end product-specific receptor (RAGE) and apurinic/apyrimidinic endonuclease 1 (APE1) genes in association with lung cancer among Han Chinese.819 patients with lung cancer and 803 cancer-free controls were recruited from Qiqihar city. Genotypes of five examined polymorphisms (RAGE gene: rs1800625, rs1800624, rs2070600; APE1 gene: rs1760944, rs1130409) were determined by ligase detection reaction method. Data were analyzed by R software and multifactor dimensionality reduction (MDR). Hardy-Weinberg equilibrium was satisfied for all five polymorphisms. Overall differences in the genotype and allele distributions were significant for rs1800625 (Pgenotype<0.0005; Pallele<0.0005), rs2070600 (Pgenotype = 0.005; Pallele = 0.004) and rs1130409 (Pgenotype = 0.009; Pallele = 0.004) polymorphisms. Haplotype C-A-A (alleles in order of rs1800625, rs1800624 and rs2070600) of RAGE gene was overrepresented in patients, and conferred a 2.1-fold increased risk of lung cancer (95% confidence interval: 1.52-2.91), independent of confounding factors. Further application of MDR method to five examined polymorphisms identified the overall best interaction model including rs2070600 and rs1130409 polymorphisms. This model had a maximal testing accuracy of 64.63% and a maximal cross-validation consistency of 9 out of 10 at the significant level of 0.006.Our findings demonstrated a potential interactive contribution of RAGE and APE1 genes to the pathogenesis of lung cancer among Han Chinese. Further studies are warranted to confirm or refute these findings.http://europepmc.org/articles/PMC3708913?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Hongming Pan
Wenquan Niu
Lan He
Bin Wang
Jun Cao
Feng Zhao
Ying Liu
Shen Li
Huijian Wu
spellingShingle Hongming Pan
Wenquan Niu
Lan He
Bin Wang
Jun Cao
Feng Zhao
Ying Liu
Shen Li
Huijian Wu
Contributory role of five common polymorphisms of RAGE and APE1 genes in lung cancer among Han Chinese.
PLoS ONE
author_facet Hongming Pan
Wenquan Niu
Lan He
Bin Wang
Jun Cao
Feng Zhao
Ying Liu
Shen Li
Huijian Wu
author_sort Hongming Pan
title Contributory role of five common polymorphisms of RAGE and APE1 genes in lung cancer among Han Chinese.
title_short Contributory role of five common polymorphisms of RAGE and APE1 genes in lung cancer among Han Chinese.
title_full Contributory role of five common polymorphisms of RAGE and APE1 genes in lung cancer among Han Chinese.
title_fullStr Contributory role of five common polymorphisms of RAGE and APE1 genes in lung cancer among Han Chinese.
title_full_unstemmed Contributory role of five common polymorphisms of RAGE and APE1 genes in lung cancer among Han Chinese.
title_sort contributory role of five common polymorphisms of rage and ape1 genes in lung cancer among han chinese.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2013-01-01
description Lung cancer is the leading cause of cancer mortality in China. Given the ubiquitous nature of gene-to-gene interaction in lung carcinogenesis, we sought to evaluate five common polymorphisms from advanced glycosylation end product-specific receptor (RAGE) and apurinic/apyrimidinic endonuclease 1 (APE1) genes in association with lung cancer among Han Chinese.819 patients with lung cancer and 803 cancer-free controls were recruited from Qiqihar city. Genotypes of five examined polymorphisms (RAGE gene: rs1800625, rs1800624, rs2070600; APE1 gene: rs1760944, rs1130409) were determined by ligase detection reaction method. Data were analyzed by R software and multifactor dimensionality reduction (MDR). Hardy-Weinberg equilibrium was satisfied for all five polymorphisms. Overall differences in the genotype and allele distributions were significant for rs1800625 (Pgenotype<0.0005; Pallele<0.0005), rs2070600 (Pgenotype = 0.005; Pallele = 0.004) and rs1130409 (Pgenotype = 0.009; Pallele = 0.004) polymorphisms. Haplotype C-A-A (alleles in order of rs1800625, rs1800624 and rs2070600) of RAGE gene was overrepresented in patients, and conferred a 2.1-fold increased risk of lung cancer (95% confidence interval: 1.52-2.91), independent of confounding factors. Further application of MDR method to five examined polymorphisms identified the overall best interaction model including rs2070600 and rs1130409 polymorphisms. This model had a maximal testing accuracy of 64.63% and a maximal cross-validation consistency of 9 out of 10 at the significant level of 0.006.Our findings demonstrated a potential interactive contribution of RAGE and APE1 genes to the pathogenesis of lung cancer among Han Chinese. Further studies are warranted to confirm or refute these findings.
url http://europepmc.org/articles/PMC3708913?pdf=render
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