Design, Synthesis and Biological Evaluation of Tasiamide Analogues as Tumor Inhibitors

Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications...

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Bibliographic Details
Main Authors: Wei Zhang, Tiantian Sun, Zhenhua Ma, Yingxia Li
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Marine Drugs
Subjects:
Online Access:http://www.mdpi.com/1660-3397/12/4/2308