Sonic hedgehog carried by microparticles corrects angiotensin II-induced hypertension and endothelial dysfunction in mice.

Sonic hedgehog carried by microparticles corrects angiotensin II-induced hypertension and endothelial dysfunction in mice.

Microparticles are small fragments of the plasma membrane generated after cell stimulation. We recently showed that Sonic hedgehog (Shh) is present in microparticles generated from activated/apoptotic human T lymphocytes and corrects endothelial injury through nitric oxide (NO) release. This study i...

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Bibliographic Details
Main Authors: Vannina González Marrachelli, Maria Letizia Mastronardi, Mamadou Sarr, Raffaella Soleti, Daniela Leonetti, María Carmen Martínez, Ramaroson Andriantsitohaina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3745429?pdf=render

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