The mechanisms and impacts of obesity on the development of liver cancer

Obesity has become a severe public health issue. Studies have shown that obesity is closely associated with metabolic disease and the development and progression of various tumors. This article summarizes the obesity-related factors in the development and progression of liver cancer, including adipo...

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Main Author:	SHI Peicen
Format:	Article
Language:	zho
Published:	Editorial Department of Journal of Clinical Hepatology 2017-10-01
Series:	Linchuang Gandanbing Zazhi
Subjects:	obesity； liver neoplasms； review
Online Access:	http://www.lcgdbzz.org/qk_content.asp?id=8536

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spelling	doaj-69f5c45e17ba439c9a17c48ebdba744e2020-11-25T01:51:09ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562017-10-0133102004200810.3969/j.issn.1001-5256.2017.10.034 The mechanisms and impacts of obesity on the development of liver cancer SHI Peicen0Department of Hepatobiliary, the Central Hospital of Shanxian County, Heze, Shandong 274300, ChinaObesity has become a severe public health issue. Studies have shown that obesity is closely associated with metabolic disease and the development and progression of various tumors. This article summarizes the obesity-related factors in the development and progression of liver cancer, including adipokines (such as leptin, insulin like growth factor-1, interleukin-6, tumor necrosis factor-α, and adiponectin), insulin, insulin resistance, oxidative stress response, intestinal microecological disorders, and regulations of PNPLA3, miRNA, TM6SF2, and JAZF1 genes. This article reviews the research advances in these mechanisms, in order to provide guidance for the prevention and treatment of liver cancer. http://www.lcgdbzz.org/qk_content.asp?id=8536obesity； liver neoplasms； review
collection	DOAJ
language	zho
format	Article
sources	DOAJ
author	SHI Peicen
spellingShingle	SHI Peicen The mechanisms and impacts of obesity on the development of liver cancer Linchuang Gandanbing Zazhi obesity； liver neoplasms； review
author_facet	SHI Peicen
author_sort	SHI Peicen
title	The mechanisms and impacts of obesity on the development of liver cancer
title_short	The mechanisms and impacts of obesity on the development of liver cancer
title_full	The mechanisms and impacts of obesity on the development of liver cancer
title_fullStr	The mechanisms and impacts of obesity on the development of liver cancer
title_full_unstemmed	The mechanisms and impacts of obesity on the development of liver cancer
title_sort	mechanisms and impacts of obesity on the development of liver cancer
publisher	Editorial Department of Journal of Clinical Hepatology
series	Linchuang Gandanbing Zazhi
issn	1001-5256 1001-5256
publishDate	2017-10-01
description	Obesity has become a severe public health issue. Studies have shown that obesity is closely associated with metabolic disease and the development and progression of various tumors. This article summarizes the obesity-related factors in the development and progression of liver cancer, including adipokines (such as leptin, insulin like growth factor-1, interleukin-6, tumor necrosis factor-α, and adiponectin), insulin, insulin resistance, oxidative stress response, intestinal microecological disorders, and regulations of PNPLA3, miRNA, TM6SF2, and JAZF1 genes. This article reviews the research advances in these mechanisms, in order to provide guidance for the prevention and treatment of liver cancer.
topic	obesity； liver neoplasms； review
url	http://www.lcgdbzz.org/qk_content.asp?id=8536
work_keys_str_mv	AT shipeicen themechanismsandimpactsofobesityonthedevelopmentoflivercancer AT shipeicen mechanismsandimpactsofobesityonthedevelopmentoflivercancer
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The mechanisms and impacts of obesity on the development of liver cancer

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