Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating

Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating

Bio-chemical sensors are expected to offer high sensitivity and specificity towards the detection of an analyte. It has been found that optical sensors based on long period fiber gratings (LPFGs) meet most of these requirements, particularly when coated with thin and high-refractive index overlays w...

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Main Authors: Sankhyabrata Bandyopadhyay, Liyang Shao, Chao Wang, Shuaiqi Liu, Qiang Wu, Guoqiang Gu, Jie Hu, Yanjun Liu, Xiaolong Chen, Zhangqi Song, Xuefeng Song, Qiaoliang Bao, Mateusz Smietana
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Sensing and Bio-Sensing Research
Online Access:http://www.sciencedirect.com/science/article/pii/S221418041930128X
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spelling doaj-69d68de277eb4175852d86d48aaed4c12020-11-25T01:31:26ZengElsevierSensing and Bio-Sensing Research2214-18042020-02-0127Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber gratingSankhyabrata Bandyopadhyay0Liyang Shao1Chao Wang2Shuaiqi Liu3Qiang Wu4Guoqiang Gu5Jie Hu6Yanjun Liu7Xiaolong Chen8Zhangqi Song9Xuefeng Song10Qiaoliang Bao11Mateusz Smietana12Department of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, ChinaDepartment of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China; Corresponding author.Department of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China; School of Engineering and Digital Arts, University of Kent, Canterbury CT27NT, United KingdomDepartment of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, ChinaFaculty of Engineering and Environment, Northumbria University, Newcastle Upon Tyne NE1 8ST, United KingdomDepartment of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, ChinaDepartment of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, ChinaDepartment of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, ChinaDepartment of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, ChinaDepartment of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, ChinaDepartment of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, ChinaDepartment of Materials Science and Engineering, ARC Centre of Excellence in Future Low-Energy Electronics Technologies (FLEET), Monash University, Clayton, Victoria 3800, AustraliaWarsaw University of Technology, Institute of Microelectronics and Optoelectronics, Koszykowa 75, 00–662 Warszawa, PolandBio-chemical sensors are expected to offer high sensitivity and specificity towards the detection of an analyte. It has been found that optical sensors based on long period fiber gratings (LPFGs) meet most of these requirements, particularly when coated with thin and high-refractive index overlays with proper bio-functionalization. In this paper, the influence of properties of the overlay material on the sensitivity of LPFG sensors to bio-analytes is analyzed. It has been observed that the sensitivity of a particular cladding mode of LPFG can be changed drastically with the adhesion of few tens of ‘nm’ of bio-layers to the surface of LPFG. “Volume refractive index sensitivity” and “add-layer sensitivity” of a particular cladding mode, dynamic range, and limit of detection of the sensors have been investigated in the context of overlay materials, bio-functionalization steps, and surrounding buffer medium. The selection criteria of the thin-film deposition technique are discussed with the aim of designing highly sensitive sensors for biological and chemical applications. Concept of optimum overlay thickness has been redefined and an effective case-specific design methodology is proposed. Keywords: Long period fiber grating, Nano-layer coating, Mode transition, Multi-layer model, Coupled mode theory, Biological and chemical sensorshttp://www.sciencedirect.com/science/article/pii/S221418041930128X
collection DOAJ
language English
format Article
sources DOAJ
author Sankhyabrata Bandyopadhyay
Liyang Shao
Chao Wang
Shuaiqi Liu
Qiang Wu
Guoqiang Gu
Jie Hu
Yanjun Liu
Xiaolong Chen
Zhangqi Song
Xuefeng Song
Qiaoliang Bao
Mateusz Smietana
spellingShingle Sankhyabrata Bandyopadhyay
Liyang Shao
Chao Wang
Shuaiqi Liu
Qiang Wu
Guoqiang Gu
Jie Hu
Yanjun Liu
Xiaolong Chen
Zhangqi Song
Xuefeng Song
Qiaoliang Bao
Mateusz Smietana
Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating
Sensing and Bio-Sensing Research
author_facet Sankhyabrata Bandyopadhyay
Liyang Shao
Chao Wang
Shuaiqi Liu
Qiang Wu
Guoqiang Gu
Jie Hu
Yanjun Liu
Xiaolong Chen
Zhangqi Song
Xuefeng Song
Qiaoliang Bao
Mateusz Smietana
author_sort Sankhyabrata Bandyopadhyay
title Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating
title_short Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating
title_full Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating
title_fullStr Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating
title_full_unstemmed Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating
title_sort study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating
publisher Elsevier
series Sensing and Bio-Sensing Research
issn 2214-1804
publishDate 2020-02-01
description Bio-chemical sensors are expected to offer high sensitivity and specificity towards the detection of an analyte. It has been found that optical sensors based on long period fiber gratings (LPFGs) meet most of these requirements, particularly when coated with thin and high-refractive index overlays with proper bio-functionalization. In this paper, the influence of properties of the overlay material on the sensitivity of LPFG sensors to bio-analytes is analyzed. It has been observed that the sensitivity of a particular cladding mode of LPFG can be changed drastically with the adhesion of few tens of ‘nm’ of bio-layers to the surface of LPFG. “Volume refractive index sensitivity” and “add-layer sensitivity” of a particular cladding mode, dynamic range, and limit of detection of the sensors have been investigated in the context of overlay materials, bio-functionalization steps, and surrounding buffer medium. The selection criteria of the thin-film deposition technique are discussed with the aim of designing highly sensitive sensors for biological and chemical applications. Concept of optimum overlay thickness has been redefined and an effective case-specific design methodology is proposed. Keywords: Long period fiber grating, Nano-layer coating, Mode transition, Multi-layer model, Coupled mode theory, Biological and chemical sensors
url http://www.sciencedirect.com/science/article/pii/S221418041930128X
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