Successful Preservation of the Bladder in a Case of Inflammatory Myofibroblastic Tumor with the Diagnostic Efficacy of ALK/p80 Immunohistochemistry and FISH Analysis: Case Report and Review of the Literature

• Main Authors: Manabu Kato, Satoru Masui, Hideki Kanda, Kiminobu Arima, Taizo Shiraishi, Yoshiki Sugimura
• Format: Article
• Language: English
• Published: Elsevier 2017-02-01
• Series: Urology Case Reports
• Subjects: Bladder inflammatory myofibroblastic tumor; ALK/p80; Fluorescence in situ hybridization
• Online Access: http://www.sciencedirect.com/science/article/pii/S2214442016302340
• ISSN: 2214-4420

Inflammatory myofibroblastic tumor is a rare benign entity of unclear etiology. It can present with histological features that include a mixture of spindle cells, myofibroblasts and inflammatory cells. Positive immunohistochemical staining for ALK/p80 is often observed, and this marker has been considered diagnostically effective. Despite having these histological features, a previous case was incorrectly diagnosed as malignant disease and was treated with extensive surgical resection. Here we present a case of inflammatory myofibroblastic tumor in the bladder, diagnosed in part based on immunohistochemical and fluorescence in situ hybridization analysis of ALK/p80. The patient was successfully treated with bladder-preserving partial cystectomy.