Studies on the restriction of murine leukemia viruses by mouse APOBEC3.

Studies on the restriction of murine leukemia viruses by mouse APOBEC3.

APOBEC3 proteins function to restrict the replication of retroviruses. One mechanism of this restriction is deamination of cytidines to uridines in (-) strand DNA, resulting in hypermutation of guanosines to adenosines in viral (+) strands. However, Moloney murine leukemia virus (MoMLV) is partially...

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Bibliographic Details
Main Authors: Silvia Sanchez-Martinez, Amanda L Aloia, Demetria Harvin, Jane Mirro, Robert J Gorelick, Patric Jern, John M Coffin, Alan Rein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3362552?pdf=render

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http://europepmc.org/articles/PMC3362552?pdf=render

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