Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

Metastasizing cancer cells rewire their metabolism to support their malignant phenotypes. Here, the authors show that the acquisition of a metastatic phenotype in breast cancer cell lines results in increased proline catabolism and that inhibition of this pathway decreases lung metastasis formation...

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Main Authors:	Ilaria Elia, Dorien Broekaert, Stefan Christen, Ruben Boon, Enrico Radaelli, Martin F. Orth, Catherine Verfaillie, Thomas G. P. Grünewald, Sarah-Maria Fendt
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15267

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spelling	doaj-69af72ab34f4448d9adc1e35ac453ca92021-05-11T07:18:41ZengNature Publishing GroupNature Communications2041-17232017-05-018111110.1038/ncomms15267Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cellsIlaria Elia0Dorien Broekaert1Stefan Christen2Ruben Boon3Enrico Radaelli4Martin F. Orth5Catherine Verfaillie6Thomas G. P. Grünewald7Sarah-Maria Fendt8Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer BiologyLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer BiologyLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer BiologyStem Cell Institute, KU LeuvenCenter for the Biology of Disease, VIB Leuven and Center for Human Genetics, KU LeuvenMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of PathologyStem Cell Institute, KU LeuvenMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of PathologyLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer BiologyMetastasizing cancer cells rewire their metabolism to support their malignant phenotypes. Here, the authors show that the acquisition of a metastatic phenotype in breast cancer cell lines results in increased proline catabolism and that inhibition of this pathway decreases lung metastasis formation in two mouse models.https://doi.org/10.1038/ncomms15267
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ilaria Elia Dorien Broekaert Stefan Christen Ruben Boon Enrico Radaelli Martin F. Orth Catherine Verfaillie Thomas G. P. Grünewald Sarah-Maria Fendt
spellingShingle	Ilaria Elia Dorien Broekaert Stefan Christen Ruben Boon Enrico Radaelli Martin F. Orth Catherine Verfaillie Thomas G. P. Grünewald Sarah-Maria Fendt Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells Nature Communications
author_facet	Ilaria Elia Dorien Broekaert Stefan Christen Ruben Boon Enrico Radaelli Martin F. Orth Catherine Verfaillie Thomas G. P. Grünewald Sarah-Maria Fendt
author_sort	Ilaria Elia
title	Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
title_short	Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
title_full	Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
title_fullStr	Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
title_full_unstemmed	Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
title_sort	proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-05-01
description	Metastasizing cancer cells rewire their metabolism to support their malignant phenotypes. Here, the authors show that the acquisition of a metastatic phenotype in breast cancer cell lines results in increased proline catabolism and that inhibition of this pathway decreases lung metastasis formation in two mouse models.
url	https://doi.org/10.1038/ncomms15267
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Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

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