Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability

Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability

DNA transcription and replication are two essential physiological processes that can turn into a threat for genome integrity when they compete for the same DNA substrate. During transcription, the nascent RNA strongly binds the template DNA strand, leading to the formation of a peculiar RNA–DNA hybr...

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Bibliographic Details
Main Authors: Carlo Rinaldi, Paolo Pizzul, Maria Pia Longhese, Diego Bonetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
R-loops
DNA damage
replication stress
ATM
ATR
DSBs
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.618157/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.618157/full

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