Mapping of the FGF14:Nav1.6 complex interface reveals FLPK as a functionally active peptide modulating excitability

Mapping of the FGF14:Nav1.6 complex interface reveals FLPK as a functionally active peptide modulating excitability

Abstract The voltage‐gated sodium (Nav) channel complex is comprised of pore‐forming α subunits (Nav1.1–1.9) and accessory regulatory proteins such as the intracellular fibroblast growth factor 14 (FGF14). The cytosolic Nav1.6 C‐terminal tail binds directly to FGF14 and this interaction modifies Nav...

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Bibliographic Details
Main Authors: Aditya K. Singh, Paul A. Wadsworth, Cynthia M. Tapia, Giuseppe Aceto, Syed R. Ali, Haiying Chen, Marcello D'Ascenzo, Jia Zhou, Fernanda Laezza
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Physiological Reports
Subjects:
accessory protein
excitability
inactivation
sodium channels
Online Access:https://doi.org/10.14814/phy2.14505

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