Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products

Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products

Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug. Extrudates were obtained under reduced torque (up to 0.3 Nm) at 100 °C to preserve the stability...

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Bibliographic Details
Main Authors: Ana Luiza Lima, Ludmila A. G. Pinho, Juliano A. Chaker, Livia L. Sa-Barreto, Ricardo Neves Marreto, Tais Gratieri, Guilherme M. Gelfuso, Marcilio Cunha-Filho
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceutics
Subjects:
hot-melt extrusion
effervescent drug product
stability
hygroscopicity
disintegration time
Online Access:https://www.mdpi.com/1999-4923/12/8/779

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https://www.mdpi.com/1999-4923/12/8/779

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