Biochemical, Anatomical, and Pharmacological Characterization of Calcitonin-Type Neuropeptides in Starfish: Discovery of an Ancient Role as Muscle Relaxants

Biochemical, Anatomical, and Pharmacological Characterization of Calcitonin-Type Neuropeptides in Starfish: Discovery of an Ancient Role as Muscle Relaxants

Calcitonin (CT) is a peptide hormone released by the thyroid gland that regulates blood Ca2+ levels in mammals. The CT gene is alternatively spliced, with one transcript encoding CT and another transcript encoding the CT-like neuropeptide calcitonin-gene related peptide (α-CGRP), which is a powerful...

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Bibliographic Details
Main Authors: Weigang Cai, Chan-Hee Kim, Hye-Jin Go, Michaela Egertová, Cleidiane G. Zampronio, Alexandra M. Jones, Nam Gyu Park, Maurice R. Elphick
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Neuroscience
Subjects:
calcitonin
echinoderm
Asterias rubens
starfish
evolution
neuropeptide
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00382/full

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