Interferon Regulatory Factor 3 Deficiency Induces Age-Related Alterations of the Retina in Young and Old Mice

Interferon Regulatory Factor 3 Deficiency Induces Age-Related Alterations of the Retina in Young and Old Mice

Age-related changes in visual function and retina structure are very common in aged animals, but the underlying mechanisms of these changes remain unclear. Here we report that the expression of interferon regulatory factor 3 (IRF3), a critical immune regulatory factor, is dramatically down-regulated...

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Bibliographic Details
Main Authors: Xi Zhang, Jingyi Zhu, Xianjun Chen, Zhang Jie-Qiong, Xue Li, Linlin Luo, Huang Huang, Wenyi Liu, Xinyuan Zhou, Jun Yan, Sen Lin, Jian Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
IRF3
retina
ERG
retinal thickness
synaptic ectopia
senescence
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00272/full

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