Recent advances in understanding dendritic cell development, classification, and phenotype [version 1; referees: 2 approved]

Recent advances in understanding dendritic cell development, classification, and phenotype [version 1; referees: 2 approved]

Dendritic cells (DCs) play an essential role in the induction of adaptive immune responses against infectious agents and in the generation of tolerance to self-antigens. In this mini-review, we summarize new evidence suggesting that the tissue of residence significantly shapes the last developmental...

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Main Authors: Andreas Schlitzer, Wei Zhang, Mei Song, Xiaojing Ma
Format: Article
Language:English
Published: F1000 Research Ltd 2018-09-01
Series:F1000Research
Online Access:https://f1000research.com/articles/7-1558/v1
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spelling doaj-6996167a35d3435d825d24613b6dd8812020-11-25T03:15:48ZengF1000 Research LtdF1000Research2046-14022018-09-01710.12688/f1000research.14793.116098Recent advances in understanding dendritic cell development, classification, and phenotype [version 1; referees: 2 approved]Andreas Schlitzer0Wei Zhang1Mei Song2Xiaojing Ma3LIMES-Institute, University of Bonn, Bonn, GermanyShanghai Institute of Cancer Research, Shanghai, ChinaDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USADepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USADendritic cells (DCs) play an essential role in the induction of adaptive immune responses against infectious agents and in the generation of tolerance to self-antigens. In this mini-review, we summarize new evidence suggesting that the tissue of residence significantly shapes the last developmental steps of DCs into locally adapted cellular entities, enabling them to perform tissue-specific tasks while maintaining the core DC properties. We also discuss recent advances that have highlighted DCs’ rather complex phenotypic and functional heterogeneity in the tumor microenvironment, based on their physical characteristics, such as activation status, maturity, and polarization, illustrating a key role for DCs in the induction of anti-tumor immunity.https://f1000research.com/articles/7-1558/v1
collection DOAJ
language English
format Article
sources DOAJ
author Andreas Schlitzer
Wei Zhang
Mei Song
Xiaojing Ma
spellingShingle Andreas Schlitzer
Wei Zhang
Mei Song
Xiaojing Ma
Recent advances in understanding dendritic cell development, classification, and phenotype [version 1; referees: 2 approved]
F1000Research
author_facet Andreas Schlitzer
Wei Zhang
Mei Song
Xiaojing Ma
author_sort Andreas Schlitzer
title Recent advances in understanding dendritic cell development, classification, and phenotype [version 1; referees: 2 approved]
title_short Recent advances in understanding dendritic cell development, classification, and phenotype [version 1; referees: 2 approved]
title_full Recent advances in understanding dendritic cell development, classification, and phenotype [version 1; referees: 2 approved]
title_fullStr Recent advances in understanding dendritic cell development, classification, and phenotype [version 1; referees: 2 approved]
title_full_unstemmed Recent advances in understanding dendritic cell development, classification, and phenotype [version 1; referees: 2 approved]
title_sort recent advances in understanding dendritic cell development, classification, and phenotype [version 1; referees: 2 approved]
publisher F1000 Research Ltd
series F1000Research
issn 2046-1402
publishDate 2018-09-01
description Dendritic cells (DCs) play an essential role in the induction of adaptive immune responses against infectious agents and in the generation of tolerance to self-antigens. In this mini-review, we summarize new evidence suggesting that the tissue of residence significantly shapes the last developmental steps of DCs into locally adapted cellular entities, enabling them to perform tissue-specific tasks while maintaining the core DC properties. We also discuss recent advances that have highlighted DCs’ rather complex phenotypic and functional heterogeneity in the tumor microenvironment, based on their physical characteristics, such as activation status, maturity, and polarization, illustrating a key role for DCs in the induction of anti-tumor immunity.
url https://f1000research.com/articles/7-1558/v1
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AT weizhang recentadvancesinunderstandingdendriticcelldevelopmentclassificationandphenotypeversion1referees2approved
AT meisong recentadvancesinunderstandingdendriticcelldevelopmentclassificationandphenotypeversion1referees2approved
AT xiaojingma recentadvancesinunderstandingdendriticcelldevelopmentclassificationandphenotypeversion1referees2approved
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