Dynamics of COX-2 Content in Mucosa of the Stomach and Duodenum on the Background of Medical Correction of NSAID Gastropathy

• Main Authors: Yu.M. Stepanov, Yu.S. Breslavets
• Format: Article
• Language: English
• Published: Publishing House Zaslavsky 2013-02-01
• Series: Gastroenterologìa
• Subjects: NSAID gastropathy; cyclooxygenase type 2 (COX-2); immunohistochemical reactions; H.pylori culture
• Online Access: http://gastro.zaslavsky.com.ua/article/view/86240

The results of immune histochemical study of cyclooxygenase type 2 (COX-2) level in 120 patients with inflammatory and erosive lesions of the stomach and duodenum on the background of long-term use of non-steroid anti-inflammatory drugs (NSAIDs) before and after treatment of damages of gastroduodenal zone are presented. Average level of COX-2 in patients with gastroduodenal lesions, caused by NSAIDs, decreased by 1.5 times and made up (2.02 ± 0.11) c.u. before treatment and (1.27 ± 0.09) c.u after treatment by the regimen № 1; it decreased by 2 times and made up (2.00 ± 0.16) c.u and (0.95 ± 0.09) c.u. relatively before and after the treatment by regimen № 2. Findings indicate the decrease of protective properties of the stomach and duodenum mucosa in case of a long-term use of NSAIDs.