New approach to heart rate control as mortality reduction method in cardiac patients: potential of a new If inhibitor, ivabradine

• Main Authors: Yu. B. Belousov, O. A. Maneshina, S. B. Erofeeva
• Format: Article
• Language: Russian
• Published: «SILICEA-POLIGRAF» LLC 2007-12-01
• Series: Кардиоваскулярная терапия и профилактика
• Subjects: heart rate; cardiovascular mortality; coronary heart disease; stable angina; f-channels; if ion currents; ivabradine
• Online Access: https://cardiovascular.elpub.ru/jour/article/view/1417

Large-scale epidemiological studies have demonstrated that heart rate (HR) is an independent risk factor, increasing total, sudden and cardiovascular mortality risk. Ivabradine specifically binds to sinus node (SN) f-channels and reduces HR. Due to its specific SN action and selective If current inhibition, ivabradine dose-responsively reduces HR at rest and maximal physical exertion, without changes in mean blood pressure. It has been shown that ivabradine is not only well-tolerated, but also possesses anti-anginal and anti-ischemic effects, as potent as those for modern angina treatment agents: beta-blockers and calcium antagonists.